|Title||HPLC/TOF-MS: An alternative to LC/MS/MS for sensitive and selective determination of polar organic contaminants in the aquatic environment|
|Publication Type||Conference Paper|
|Year of Publication||2003|
|Authors||Benotti, MJ, P Ferguson, L, Rieger, RA, Iden, CR, Heine, CE, Brownawell, BJ|
|Conference Name||Acs Symposium Series|
Isobaric interferences in environmental samples can compromise trace LC-MS analysis of polar organic chemicals when using single quadrupole instruments in selected ion monitoring (SIM) mode. HPLC-MS/MS with triple quadrupole instruments in multiple reaction monitoring (MRM) mode is the conventional approach for increasing selectivity and improving sensitivity. Time-of-flight (ToF) MS offers an alternative approach with higher mass resolving power and full spectral sensitivity. Extracts from STP effluent were evaluated for PPCPs using three different types of Micromass, Inc. mass spectrometers: a single quadrupole (LCZ™), a triple quadrupole (Quattro LC ™), and an orthogonal acceleration ToF instrument (LCT ™). HPLC-ToF-MS provided significant S/N improvement over SIM. © 2003 American Chemical Society.