HPLC/TOF-MS: An alternative to LC/MS/MS for sensitive and selective determination of polar organic contaminants in the aquatic environment

TitleHPLC/TOF-MS: An alternative to LC/MS/MS for sensitive and selective determination of polar organic contaminants in the aquatic environment
Publication TypeConference Paper
Year of Publication2003
AuthorsBenotti, MJ, P Ferguson, L, Rieger, RA, Iden, CR, Heine, CE, Brownawell, BJ
Conference NameAcs Symposium Series
Date Published12/2003
Abstract

Isobaric interferences in environmental samples can compromise trace LC-MS analysis of polar organic chemicals when using single quadrupole instruments in selected ion monitoring (SIM) mode. HPLC-MS/MS with triple quadrupole instruments in multiple reaction monitoring (MRM) mode is the conventional approach for increasing selectivity and improving sensitivity. Time-of-flight (ToF) MS offers an alternative approach with higher mass resolving power and full spectral sensitivity. Extracts from STP effluent were evaluated for PPCPs using three different types of Micromass, Inc. mass spectrometers: a single quadrupole (LCZ ), a triple quadrupole (Quattro LC ), and an orthogonal acceleration ToF instrument (LCT ). HPLC-ToF-MS provided significant S/N improvement over SIM. © 2003 American Chemical Society. ™ ™ ™